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科学大讲堂 | 阿尔茨海默症的分子机制
2147 人阅读发布时间：2018-06-14 16:44
Molecular Mechanisms of Alzheimer’s Disease
阿尔茨海默症的分子机制
阿尔茨海默症的分子机制
Alzheimer’s Disease is characterized by cognitive impairment, some causative factors being synaptic loss and defective neurogenesis. On a molecular level of progressive neurodegeneration, there is formation of amyloid-β(Aβ)-containing plaques and nerofibrillary tangles composed of hyperphoshorylated tau. The following diagram illustrates some proposed pathways which have been implicated in synaptotoxicity in Alzheimer’s Disease, driven either directly or indirectly by Aβ. The cause for most Alzheimer’s cases is still mostly unknown except for 1% to 5% of cases where genetic differences have been identifiled. Several competing hypotheses exist trying to explain the cause of the disease.
阿尔茨海默病的特征是认知障碍，一些致病因素是突触丧失和神经发生缺陷。在进行性神经变性的分子水平上，形成含有淀粉样蛋白-β（Aβ）的斑块和由高度磷酸化的 tau 组成的神经纤维缠结（neurofibrillary tangles）。下图说明了一些与阿尔茨海默病的突触毒性有关的，由 Aβ直接或间接驱动的提出的途径。大多数阿尔茨海默病病例的原因仍然大部分是未知的，除了 1％ 至 5％ 的遗传差异已被鉴定的病例。目前存在几个相互竞争的假设，试图解释疾病的原因。
An Extensive Range of Research Antibodies
Biorbyt offers a rich resource of research antibodies which cover most of the cancer signaling pathways. We only include antibodies in our catalog which have been validated first, some in a variety of different applications. Validation date, customer reviews and recent citations for our antibodies can be viewed before you decide to purchase. As well as antibodies, we can supply you with antibody related products, all of which are covered by our auality guarantee.
Biorbyt 提供丰富的研究抗体资源，覆盖大部分癌症信号通路。我们产品目录中的抗体，都经过不同的实验应用的验证。在您决定购买之前，可以查看我们抗体的验证日期，客户评论和最新引用。除抗体外，我们还可以为您提供抗体相关产品，所有这些产品都在质量保证范围内。
1. Customer Product reviews / 客户产品评论
2. Tens of 1000s to choose from / 多种产品选择
3. Validated for use in a variety of techniques / 多种产品验证
4. Expert technical support available where you are / 专业技术支持
Alzheimer’s Research Antibodies
| Name | Catalog Number | Applications | Reacts with |
| ABPP (phospho-Ser730) antibody | orb4528 | WB, IHC-P, P-ELISA | Human, Mouse, Rat |
| Apolipoprotein E antibody | orb69429 | ELISA, WB, IHC-P, IF/ICC, FACS | Human |
| APP antibody | orb216018 | WB, IHC-P | Human, Mouse, Rat |
| beta Amyloid antibody | orb10084 | WB, IHC-P, P-ELISA | Human, Rat |
| BPTF antibody | orb181646 | ELISA, WB, IHC-P | Human |
| CDK5 antibody | orb10359 | WB, IHC-P, P-ELISA | Human, Mouse, Rat |
| CLSTN1 antibody | orb156407 | WB, IHC-P, FACS, P-ELISA | Human, Mouse, Rat |
| presenilin 2 antibody | orb6805 | WB, IHC-P, P-ELISA | Human, Mouse, Rat |
| Tau antibody | orb11453 | ELISA, WB, IHC-P, IHC-Fr, IF/ICC | Human, Mouse, Rat |
Alzheimer’s Signaling References
1. Crews, L. and Masliah, E. Molecular mechanisms of neurodegeneration in Alzheimer’s disease. Hum. Mol. Genet. (2010) 19 (R1): R12-R20. doi: 10.1093/hmg/ddq160
2. Benilova, I., et al. The toxic Aβ oligomer and Alzheimer’s disease: an emperor in need od clothes. Nature Neuroscience. (2012) 15, 349-357 doi: 10.1038/nn.3028
Visit www.biorbyt.com to see our full range of Alzheimer’s research antibodies and associated products.