科学大讲堂 | 信号通路专题系列一：Nf-κB信号通路

信号通路专题系列一：Nf-κB Signaling Pathway

Transcriptional programs regulated by Nf-κB are essential to the development and maintenance of the immune system, skeletal system and epithelium. In these settings, Nf-κB contributes to the control of cell survival, differentiation and proliferation. Aberrant activation of Nf-κB has been associated with numerous diseases such as cancer, autoimmune disease, neurodegenerative diseases and cardiovascular disease. The Nf-κB signaling pathway is most characterized and well understood in its role in chronic inflammation and auto-immune disease.  

Nf-κB调控的转录程序对免疫系统，骨骼系统和上皮细胞的发育和维持至关重要。在这些环境中，Nf-κB有助于控制细胞存活，分化和增殖。 Nf-κB异常活化与许多疾病有关，如癌症，自身免疫性疾病，神经退行性疾病和心血管疾病。Nf-κB信号传导途径在慢性炎症和自身免疫疾病中的作用最具特征并且很好理解。

Nf-κB proteins are characterized by the presence of a 300-amino acid sequence on the N-terminus called the Rel homology domain (RHD). Five members comprise the Nf-κB protein family: RelA/p65, RelB, c-Rel, p50 and p52. These proteins bind to kB sites as homo- or hetero- dimers which can have a positive or negative impact on gene transcription.
There are two types of Nf-κB signaling pathway: canonical and non-canonical. Both require activation through post translational modifications of IkB inhibitors. Canonical pathway activation predominantly occurs through BCR, TCR, TLR4, IL-1R or TNF-R receptors, whereas the non-canonical pathway involves receptor activation of CD40L, BAFF or lymphotoxin-B.

Nf-κB蛋白质的特征在于在N-末端存在称为Rel同源性结构域（RHD）的300个氨基酸的序列。Nf-κB蛋白家族由五个成员组成：RelA / p65，RelB，c-Rel，p50和p52。这些蛋白作为同源或异源二聚体结合到kB位点上，可能对基因转录产生正面的或负面的影响。
Nf-κB信号传导途径有两种类型：典型和非典型。两者都需要通过IkB抑制剂的翻译后修饰来激活。典型途径活化主要通过BCR，TCR，TLR4，IL-1R或TNF-R受体发生，而非经典途径涉及CD40L，BAFF或淋巴毒素-B的受体活化。
 

Helping your research

Biorbyt has an extensive range of small molecules available as research reagents to target proteins in the NF-κB pathway. We provide the best service and a simple buying process allowing you to focus on your valuable research. Take a look at our product pages where you will find competitive pricing, lead times, and easy delivery options. If you have any questions, just ask us.

Biorbyt拥有广泛的小分子，可用作研究试剂以靶向NF-κB通路中的蛋白质。我们提供最好的服务和简单的购买流程，让您专注于您的宝贵研究。看看我们的产品页面，您可以找到具有竞争力的价格，交货期和易于交付的选项。如果您有任何问题，请联系我们。

Nf-κB信号通路相关抗体推荐：
 

Catalogue Number	Product name	Clonality / Source	Applications
orb11118	NFkB p65 antibody	Rabbit Polyclonal	ELISA, WB, IHC-P, IHC-Fr, IF/ICC, FACS
orb4793	RelB antibody	Rabbit Polyclonal	WB, IHC-P, FACS, P-ELISA
orb69437	c-Rel antibody	Mouse Monoclonal	ELISA, WB, IHC-P, IF/ICC, FACS
orb69448	NFKB1 antibody	Mouse Monoclonal	ELISA, WB, IHC-P, IF/ICC, FACS
orb14431	NFkB p100/p52 antibody	Rabbit Polyclonal	WB, IHC-P, IF/ICC
orb11489	TLR4 antibody	Rabbit Polyclonal	ELISA, IHC-P, IHC-Fr, IF/ICC
orb348859	CD40L antibody	Human Monoclonal	WB, IHC-P
orb74394	BAFF antibody	Rabbit Polyclonal	ELISA, WB, IHC-P, IF/ICC
orb357915	IL1 Receptor antibody	Rabbit Polyclonal	ELISA, WB, IHC-P