【Biorbyt新产品】COVID19 Biomarker Panel: 肽生物标志物预测COVID-19的严重性

发布时间:2021-05-10 15:51 点击次数:

【Biorbyt新产品】COVID19 Biomarker Panel: 肽生物标志物预测COVID-19的严重性

原创 biorbyt 英国biorbyt 1周前

Tailored Biomarker Tests for COVID-19




COVID-19 is an infectious disease caused by SARS coronavirus 2 (SARS-CoV-2) and is the cause of the COVID-19 pandemic. Scientists across the world are working together to accelerate the research and development process to contain its spread.



Predictive COVID-19 Disease Severity Test / COVID-19 疾病严重程度预测试验

● The test classifies and predicts COVID-19 disease severity, based on host response to COVID-19. 



●The test predicts whether COVID-19 patients: 



ⅰ. are likely to develop severe disease (WHO 3 vs WHO 4-7);

     可能发展为严重疾病(WHO 3 vs WHO 4-7);


ⅱ. will need invasive ventilation;



ⅲ. are likely to survive if they have severe disease.



● The purpose of the test is to demonstrate treatment efficacy, elucidate the MoA of COVID-19 therapeutics in development and to provide a readout of what the disease would have looked like without treatment.



● The test may also be used as a tool for severe disease risk stratification in an exploratory context.




● A standardized, ultra-high-throughput clinical platform for serum and plasma proteomics



● Platform enables high precision quantification of 180 human proteomes per day at low cost



● 27 biomarkers are differentially expressed between WHO severity grades for COVID-19



● Biomarkers include proteins not previously associated with COVID-19 infection


Overlaid chromatogram of the biomarker peptides included in the multiplexed targeted proteomic assay. The assay was developed to quantitate 50+ peptides in a 10 min LC run.



Early Access Program 抢先体验计划

Kit Reagents (Reference Peptides)/ 试剂盒试剂(参考肽)

· 52 Synthetic reference peptides (calibrators) (approx 1ug per peptide per batch) / 52种合成参考肽(校准品)(每批每肽约1ug)

· 52 Isotopically labelled internal standard peptides (approx 100ng per peptide per sample) / 52种同位素标记的内标肽(每个样品每个肽约100ng)

Quantity / Format /数量/格式

104 peptides in 2-3ml labelled Eppendorf vials 


Shipping /运输

Ambient temp. / 环境温度

Storage /储存

Dried down & stored at -20 Celsius / 干燥&-20摄氏度下储存

Shelf life /保质期

12 months /12个月

Number of samples per kit / 每个盒子的样本数


QCs and Calibrators  / QC和校准品


Protocols included (SOPs) /实验方案

A detailed, step-by-step protocol with SOPs for sample preparation, mass spectrometry system set up and the results we have generated previously /提供使用SOP,进行详细的分步操作的方案,用于样品制备,质谱系统设置以及我们先前生成的结果


Get your COVID-19 Biomarker Panel today


产品名称:COVID19 Biomarker Panel

产品货号: orb751448


or contact us for more information



1. Messner, C. B., Demichev, V., Wendisch, D., Michalick, L., White, M., Freiwald, A., Textoris-Taube, K., Vernardis, S. I., Egger, A., Kreidl, M., Ludwig, D., Kilian, C., Agostini, F., Zelezniak, A., Thibeault, C., Pfeiffer, M., Hippenstiel, S., Hocke, A., von Kalle, C., Campbell, A., Hayward, C., Porteous, D. J., Marioni, R. E., Langenberg, C., Lilley, K. S., Kuebler, W. M., Mülleder, M., Drosten, C., Suttorp, N., Witzenrath, M., Kurth, F., Sander, L. E. and Ralser, M. 2020. Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection. Cell Systems, 11(1), 11-24.e4. Available from: doi: 10.1016/j.cels.2020.05.012

2. Demichev, V., Tober-Lau, P., Nazarenko, T., Thibeault, C., Whitwell, H., Lemke, O., Röhl, A., Freiwald, A., Szyrwiel, L., Ludwig, D., Correia-Melo, C., Helbig, E. T., Stubbemann, P., Grüning, N., Blyuss, O., Vernardis, S., White, M., Messner, C. B., Joannidis, M., Sonnweber, T., Klein, S. J., Pizzini, A., Wohlfarter, Y., Sahanic, S., Hilbe, R., Schaefer, B., Wagner, S., Mittermaier, M., Machleidt, F., Garcia, C., Ruwwe-Glösenkamp, C., Lingscheid, T., de Jarcy, L. B., Stegemann, M. S., Pfeiffer, M., Jürgens, L., Denker, S., Zickler, D., Enghard, P., Zelezniak, A., Campbell, A., Hayward, C., Porteous, D. J., Marioni, R. E., Uhrig, A., Müller-Redetzky, H., Zoller, H., Löffler-Ragg, J., Keller, M. A., Tancevski, I., Timms, J. F., Zaikin, A., Hippenstiel, S., Ramharter, M., Witzenrath, M., Suttorp, N., Lilley, K., Mülleder, M., Sander, L. E., Ralser, M. and Kurth,. 2020. A Time-Resolved Proteomic And Diagnostic Map Characterizes COVID-19 Disease Progression And Predicts Outcome. Cold Spring Harbor Laboratory. Available from: doi:10.1101/2020.11.09.20228015.

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