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【Biorbyt 产品】人源成纤维细胞生长因子受体(FGFRs)重组蛋白

发布时间:2021-05-20 10:59 点击次数:

【Biorbyt 产品】人源成纤维细胞生长因子受体(FGFRs)重组蛋白

原创 biorbyt 英国biorbyt 
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成纤维细胞生长因子受体(FGFRs)是与FGF结合的跨膜受体家族,参与调节细胞的生长和增殖,血管生成和许多发育过程。它们是高度保守的,由三个能使配体结合的细胞外免疫球蛋白型结构域IgI,IgII和IgIII组成,一个跨膜结构域和一个发挥其下游信号传导作用的细胞内酪氨酸激酶结构域。FGFR / FGF激活的信号转导通路与多种癌症有关。因此,FGFR抑制剂正在许多癌症研究中作为潜在的治疗剂进行研究(1,2)。

Fibroblast Growth Factor Receptors (FGFRs) are a family of FGF-binding transmembrane receptors involved in regulating cell growth and proliferation, angiogenesis, and numerous developmental processes. They are highly conserved, consisting of three extracellular immunoglobulin-type domains, IgI, IgII, and IgIII, which enable ligand binding, a transmembrane domain, and an intracellular tyrosine kinase domain which exerts its downstream signaling effects. The signaling pathway activated by FGFR/FGF has been implicated in several cancers; consequently, FGFR inhibitors are being investigated as potential therapeutic agents in many cancer studies (1,2). 由FGFR基因的可变剪接产生的FGFR同工型显示组织特异性表达和各种FGF结合特性。使用新颖的稳定的哺乳动物表达系统,Biorbyt可以提供多种高纯度和低内毒素重组人成纤维细胞生长因子受体,涵盖所有主要的剪接变体。FGFR isoforms generated from alternative splicing of the FGFR genes display tissue-specific expression and various FGF binding properties. Using a novel stable mammalian expression system, Biorbyt can provide multiple high purity and low endotoxin Recombinant Human Fibroblast Growth Factor Receptors, covering all the major splice variants. 

哺乳动物表达体系:Biorbyt重组人源FGFR1b和FGFR1c蛋白

 

剪接变体FGFR1b是代表FGFR1上皮变体的同工型,而FGFR1c是FGFR1的间充质变体。这些成纤维细胞生长因子受体配有C末端10 x组氨酸标签,易于检测。与使用类似产品上的Fc标签相比,这种较小的标签具有明显的功能优势。

The splice variant FGFR1b is an isoform representing an epithelial variant of FGFR1, while FGFR1c is a mesenchymal variant of FGFR1. These Fibroblast Growth Factor Receptors are supplied with a C-terminal 10 x Histidine tag for ease of detection. This smaller tag has distinct functional advantages over the use of the Fc-tag found on similar products. 

Catalog No.

Name

orb668917

Human FGFR1b protein

orb668918

Human FGFR1c protein

 

专注于质量,Biorbyt重组人源FGFR2b和FGFR2c蛋白

 

FGFR2b是剪接的同工型,代表FGFR2的上皮变体,而FGFR2c是FGFR2的间质变体。Biorbyt可以提供经过验证的高质量蛋白质,以适合众多实验室应用,例如Western Blot分析。

FGFR2b is an alternatively spliced isoform representing an epithelial variant of FGFR2 while FGFR2c is a mesenchymal variant of FGFR2. Biorbyt can offer high-quality, validated proteins to suit numerous laboratory applications, such as Western Blot analysis. 

Catalog No.

Name

orb668919

Human FGFR2b protein

orb668920

Human FGFR2c protein

 

References

1. Chae, Y. K. et al. Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application. Oncotarget vol. 8,9 (2017): 16052-16074.

2. Porta, R. et al. FGFR a promising druggable target in cancer: Molecular biology and new drugs. Crit Rev Oncol Hematol. vol. 113 (2017): 256-267.


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