Biorbyt全蛋白新冠ELISA IgG和IgM检测试剂盒上市！

        Biorbyt 和 Daresbury Proteins 很高兴地宣布推出共同开发的全蛋白Covid-19 IgG 和 IgM ELISA检测试剂盒，提供对因 Covid-19 感染和疫苗接种计划而产生的特异性抗体的灵敏和可靠的测量。

        Biorbyt and Daresbury Proteins are excited to announce the launch of novel Covid-19 IgG and IgM ELISA assays, providing sensitive and reliable measurements of specific antibodies as a result of Covid-19 infections and vaccination programmes.

 

         我们制造的三聚体 Spike 蛋白——最有价值的 Covid-19 抗原——确保超高灵敏度。该三聚体 Spike 蛋白是在人类细胞培养中生产的，因此与当前疫苗完全匹配，为评估这些疫苗的功效提供了最佳工具。

         We manufacture trimeric Spike proteins — the most valuable Covid-19 antigen — ensuring the highest sensitivity of the resulting test. They are produced in human cell culture and therefore are the exact match of the current vaccines, providing the best tool to assess the efficacy of those vaccines.

 

         该新冠三聚体 Spike 蛋白是通过专有表达质粒中的密码子优化序列独特表达的，具有广泛翻译后修饰的大分子量蛋白质。

Uniquely expressed large MW proteins with extensive post-translational modifications via codon optimised sequences in proprietary expression plasmids.

         具备超稳定的三聚体尖峰作为丰富的捕获抗原，确保最准确地检测康复或接种疫苗的人体内循环特异性抗 SARS-CoV-2 抗体。

Super stable trimeric Spikes as abundant capture antigens ensuring the most faithful detection of circulating specific anti-SARS-CoV-2 antibodies in recovered or vaccinated people.

优势/Advantages

● 需要少量的血液，可以在家中采集。/ Small volumes of blood required which can be collected at home.

● 极其灵敏可靠的抗体测定方法。/ Extremely sensitive and reliable antibody-measuring method.

● 运行所需的最少消耗品和仪器。/ Minimum consumables and instruments required to run.

● 区分对关注的各种突变体/变体的血清学反应；具有潜在的预后价值。/ Distinguishes between serological response to various mutants/variants of concern; has a potential prognostic value.

 

替代抗体检测的缺点/Disadvantages of alternative antibody assays

● 目前大多数商业诊断试剂盒都以重组核衣壳或小得多的 Spike 片段作为其成分。/ Most of the current commercial diagnostic kits have either recombinant Nucleocapsid or much smaller fragments of Spike as their components.

● 前者无法区分 SARS-CoV-2 和其他冠状病毒，如流感或普通感冒，导致检测结果的特异性问题。此外，它不能用于测量接种者血液中的 SARS-CoV-2 特异性抗体。/ The former cannot distinguish between SARS-CoV-2 and other coronaviruses such as flu or common cold, presenting specificity issues of the resulting tests. Moreover, it cannot be used to measure SARS-CoV-2 specific antibodies in the blood of vaccinated people.

● 基于受体结合域 (RBD) 的测试会导致灵敏度问题，因为它们只能检测一小部分特异性抗体。/ The Receptor Binding Domain (RBD) based tests cause sensitivity problems since they can only detect a small portion of specific antibodies.

● 由于中和逃逸效应，在测量对其他棘突突变形式的血清学反应时容易失败。/ Prone to failure when measuring serological response to other mutant forms of Spike due to neutralisation escape effect.

 

定量IgG和IgM ELISA / Quantitative IgG & IgM ELISA

● COVID-19 ELISA IgG 检测有两种形式：

The COVID-19 ELISA IgG test is available in two formats:

 

格式 1：一个 96 孔板，每孔中包被的 Spike 蛋白浓度为 2 ug/ml，以及运行 ELISA 方案所需的所有试剂。提供了经过完整测试的实验协议。有效期为收到包裹后7天。

Format 1: A 96 well plate with coated Spike protein at a concentration of 2 ug/ml in each well and all required reagents to run an ELISA protocol. A thoroughly tested protocol is provided. Expiration date is 7 days from the receipt of package.

 

格式 2：所有试剂均提供给终端用户。板子包被在终端用户环境中进行，允许长期储存 COVID-19 Spike 蛋白。

Format 2: All reagents are provided to end user. Plate coating is carried out within the end user environment, allowing long term storage of the COVID-19 Spike protein.

 

 

 

 

 

 

即将推出！Coming soon!

 

允许测量所有变体蛋白质的多重测定。

Multiplex assay allowing the measurements of all variant proteins.

各种 COVID-19 变体的分离重组蛋白

Isolated recombinant proteins of the various COVID-19 variants

Name	Catalog #	Application	Reactivity
SARS-CoV-2 trimeric soluble full-length Spike protein, Beta variant, S protein	orb864237	SDS-PAGE, ELISA	Human
SSARS-CoV-2 trimeric soluble full-length Spike protein, Gamma variant, S protein	orb864238	SDS-PAGE, ELISA	Human
SARS-CoV-2 trimeric soluble full-length Spike protein, B1.617 cluster, S protein	orb864239	SDS-PAGE, ELISA	Human
SARS-CoV-2 trimeric soluble full-length Spike protein, Delta variant, S protein	orb864240	SDS-PAGE, ELISA	Human
SARS-CoV-2 trimeric soluble full-length Spike protein, Alpha variant, S protein	orb864241	SDS-PAGE, ELISA	Human

 

 

更多检测结果：